Linked Life Data

7238657

Source:http://linkedlifedata.com/resource/pubmed/id/7238657

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-8-10
pubmed:abstractText
Erythropoietin-responsive cells (ERC) were reduced to very low levels in post-hypoxic polycythemic mice by intraperitoneal injection of 60 mg/kg-mouse of busulfan. Repeated injections of 5 units erythropoietin (Ep), 1, 2, and 3 days after busulfan repopulated the ERC compartment. Therefore, injection of a small test dose of Ep on day 5 induced a considerable wave of erythropoiesis. When busulfan-treated polycythemic mice received 5 mg of dexamethasone together with Ep injections they responded to the test dose of Ep with very minor increases in iron incorporation, which would indicate that a very small increase in the ERC population induced by Ep took place. These results suggest that the inhibitory action of dexamethasone on erythropoiesis is exerted not only by inhibiting the Ep-induced differentiation of ERC into proerythroblasts, but also by inhibiting the effect of the hormone on the amplification of the ERC compartment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
444-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Inhibition by dexamethasone of erythropoietin-induced amplification of the erythropoietin-responsive cell compartment.
pubmed:publicationType
Journal Article