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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1981-8-10
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pubmed:abstractText |
The effects of glutamate and aspartate antagonists were studied on limb-jerk frequency and EEG patterns in rats made epileptic by cobalt implantation in the sensorimotor cerebral cortex. The results of this study were as follows: (1) alpha-Amino-4-phosphonobutyric acid (0.055--1.10 mM) decreased or completely prevented the epileptic manifestations. The effect was reversible 30 min after washing with artificial CSF solution. (2) DL-Pyroglutamic acid completely abolished the myoclonic jerks and EEG spikes. (3) alpha-Amino-5-phosphonovaleric acid and alpha-D-amino-adipic acid significantly reduced the frequency of epileptic spikes and myoclonic jerks. (4) Other analogs, alpha-amino-3-phosphonopropionic acid (0.6 mM), alpha-amino phosphonocaproic acid (0.95), and hydroxy-3-amino pyrrolidone-2 were without effect. (5) Glutamate itself did not decrease the epileptic manifestations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0013-9580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
289-96
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7238433-Amino Acids,
pubmed-meshheading:7238433-Aminobutyric Acids,
pubmed-meshheading:7238433-Animals,
pubmed-meshheading:7238433-Aspartic Acid,
pubmed-meshheading:7238433-Cerebral Cortex,
pubmed-meshheading:7238433-Electroencephalography,
pubmed-meshheading:7238433-Epilepsy,
pubmed-meshheading:7238433-Female,
pubmed-meshheading:7238433-Glutamates,
pubmed-meshheading:7238433-Organophosphorus Compounds,
pubmed-meshheading:7238433-Rats,
pubmed-meshheading:7238433-Seizures
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pubmed:year |
1981
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pubmed:articleTitle |
Is glutamate a trigger factor in epileptic hyperactivity?
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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