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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1981-8-27
|
| pubmed:abstractText |
Over 90 different compounds having structural similarities to barbituric acid were analyzed by radioimmunoassay (RIA) using 125I-secobarbital reagents (Roche). Affinities were compared with molecular structures and a number of observations are made. It was found that all definitive components of the 5,5-dialkyl barbituric acid ring structure were essential for reactivity with the Roche RIA reagents; structural changes at any position of the ring reduced reactivity. No compounds studied were found to be more reactive than secobarbital [5-allyl-3-(1-methylbutyl) barbituric acid] and RO-2-1126[5-allyl-5-(1-carbamoylisopropyl) barbituric acid (the hapten used to prepare the RIA antibody)]. Changes in the 5-allyl and/or the 5-(1-methylbutyl) groups of secobarbital resulted in decreased reactivity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0009-9309
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
317-52
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading | |
| pubmed:year |
1981
|
| pubmed:articleTitle |
Barbiturates--structure versus RIA reactivity.
|
| pubmed:publicationType |
Journal Article
|