Linked Life Data

7236698

Source:http://linkedlifedata.com/resource/pubmed/id/7236698

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-8-10
pubmed:abstractText
1. The acyl-CoA:lysophosphatidylcholine acyltransferase system in rat lung microsomes was found to utilize selectively 1-[1-14C]palmitoyl-sn-glycero-3-phosphocholine when compared with 1-[9,10-3H2]stearoyl-sn-glycero-3-phosphocholine. This result was found with either palmitoyl-CoA, linoleoyl-CoA or an equimolar mixture of these acyl donors and confirms recent data reported by Holub, Piekarski and Possmayer (Can. J. Biochem. 58 (1980) 434-439). 2. The selective utilization of palmitoyl lysophosphatidylcholine from a mixture of lysophosphatidylcholine species may cause an increased isotopic ratio in phosphatidylcholine when compared with that of total lysophosphatidylcholine. Thus, when rats were injected with a single doubly labelled species, i.e. 1-[9,10-3H2]palmitoyl-sn-glycero-3-phospho[methyl-14C]choline, the isotopic ratio in both total and disaturated phosphatidylcholine from lung was nearly identical to that of the injected substrate. This suggested a direct acylation by lung acyl-CoA:lysophosphatidylcholine acyltransferases. By contrast, when a mixture of 1-[9,10-3H2]palmitoyl-sn-glycero-3-phospho[methyl-14C]choline and 1-stearoyl-sn-glycero-3-phospho[methyl-14C]choline was injected, the 3H/14C ratio in disaturated lung phosphatidylcholine increased to about 1.4-fold that of the injected substrate. 3. These data indicate that increased isotopic ratios in disaturated phosphatidylcholine of lung tissue, after intravenous injection of lysophosphatidylcholine, do not necessarily point to the involvement of lysophosphatidylcholine:lysophosphatidylcholine transacylase in disaturated phosphatidylcholine formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
664
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Selective utilization of palmitoyl lysophosphatidylcholine in this synthesis of disaturated phosphatidylcholine in rat lung: a combined in vitro and in vivo approach.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't