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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-7-20
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pubmed:abstractText |
The influence of exogenous oestrogen on the rate of synthesis of the apoprotein B of very-low-density lipoprotein by embryonic chick liver has been examined at various stages of development. Significant synthesis of apoprotein B was found in the absence of hormone treatment as early as day 6 of egg incubation. This basal level of apoprotein B synthesis varied from 2.5--6% of total protein synthesis. Embryos at day 10 or earlier treated with oestradiol exhibited no increase in the basal level of apoprotein B synthesis. Embryos at day 11 responded to oestradiol slightly and, from days 12 to 20, oestrogen treatment raised the relative rate of apoprotein B synthesis significantly above basal values: the maximal rate was about 16% of total protein synthesis. The anti-oestrogen tamoxifen citrate abolished the hormone-induced increase in apoprotein B synthesis and was not itself oestrogenic. The basal level of apoprotein B production was not sensitive to tamoxifen citrate, either in relatively early or in later stages of development. The basal level of apoprotein B synthesis, therefore, is oestrogen-independent and under developmental control distinct from the hormone-sensitive synthesis. The ontogeny of oestrogen-responsiveness of apoprotein B production appears to parallel the acquisition of the hepatic oestrogen-receptor system [Lazier (1978) Biochem. J. 174, 143--152].
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-170918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-176920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-177871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-179536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-182719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-188805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-208801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-218611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-226789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-230463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-367848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-390655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-4370392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-440416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-447748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-455441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-508284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-5501071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-558117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-562756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-637847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-649584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-687351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-697747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-6986172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-7378356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-7378364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-876358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236235-914873
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
192
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7236235-Animals,
pubmed-meshheading:7236235-Apolipoproteins,
pubmed-meshheading:7236235-Chick Embryo,
pubmed-meshheading:7236235-Dose-Response Relationship, Drug,
pubmed-meshheading:7236235-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:7236235-Estradiol,
pubmed-meshheading:7236235-Lipoproteins, VLDL,
pubmed-meshheading:7236235-Liver,
pubmed-meshheading:7236235-Organ Specificity,
pubmed-meshheading:7236235-Tamoxifen,
pubmed-meshheading:7236235-Time Factors
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pubmed:year |
1980
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pubmed:articleTitle |
Synthesis of apoprotein B of very low density lipoprotein in embryonic-chick liver. Development of responsiveness of oestrogen.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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