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rdf:type |
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lifeskim:mentions |
umls-concept:C0002565,
umls-concept:C0018927,
umls-concept:C0018966,
umls-concept:C0041256,
umls-concept:C0439849,
umls-concept:C0441655,
umls-concept:C0522534,
umls-concept:C0681814,
umls-concept:C0851285,
umls-concept:C1521801,
umls-concept:C1882726
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pubmed:issue |
2
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pubmed:dateCreated |
1981-7-20
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pubmed:abstractText |
1. Administration of haematin to rats decreases 5-aminolaevulinate synthase activity in whole liver homogenates. 2. An inverse relationship between this decrease and the increase in saturation of apo-(tryptophan pyrrolase) with haem is observed during the initial phase of treatment with haematin. 3. Significant changes in both functions are caused by a 1 mg/kg dose of haematin, whereas the maximum effects are achieved by the 5 mg/kg dose. 4. Prevention by allopurinol of the conjugation of exogenously administered haematin with apo-(tryptophan pyrrolase) renders this haem available for further repression of 5 aminolaevulinate synthase. 5. The various aspects of the relationship between synthase activity and the haem saturation of tryptophan pyrrolase are discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-1098646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-1147435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-1147902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-1212203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-1238396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-1259432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-21336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-4354741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-4400410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-446865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-4656595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-4791047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-4862944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-4955218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-5058676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-5131732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-5916943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-5935350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-6446903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-681348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-687356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-7396848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-819007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-880248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-911321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-970951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-970967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7236220-976299
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
192
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7236220-5-Aminolevulinate Synthetase,
pubmed-meshheading:7236220-Allopurinol,
pubmed-meshheading:7236220-Animals,
pubmed-meshheading:7236220-Dose-Response Relationship, Drug,
pubmed-meshheading:7236220-Heme,
pubmed-meshheading:7236220-Hemin,
pubmed-meshheading:7236220-Kinetics,
pubmed-meshheading:7236220-Liver,
pubmed-meshheading:7236220-Male,
pubmed-meshheading:7236220-Rats,
pubmed-meshheading:7236220-Starvation,
pubmed-meshheading:7236220-Tryptophan Oxygenase
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pubmed:year |
1980
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pubmed:articleTitle |
Tryptophan pyrrolase in haem regulation. Experiments with administered haematin and the relationship between the haem saturation of tryptophan pyrrolase and the activity of 5-aminolaevulinate synthase in rat liver.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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