Linked Life Data

7232258

Source:http://linkedlifedata.com/resource/pubmed/id/7232258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-7-20
pubmed:abstractText
Four-week-old male broiler chickens were intubated with a single dose of purified T-2 toxin at 2.5 mg/kg body weight. The brain concentrations of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) and selected blood components were determined in T-2 toxin treated and control chickens at 4, 12, 24, and 48 hr after the toxin treatment. The brain DA concentration of T-2 treated chickens was significantly greater at 12 and 24 hr, whereas brain NE was lower at 24 and 48 hr after toxin treatment as compared with controls. The brain 5-HT level was not altered by T-2 toxin. Serum cholesterol was increased at 4 and 12 hr after T-2 treatment. The serum LDH and GOT activities were not changed by T-2 toxin. T-2 treated chickens had greater packed cell volume and hemoglobin than controls at 24 hr after dosing. Red blood cell counts were not affected but white blood cell counts were decreased during the 12 to 48 hr period after T-2 treatment. The results of this study suggest that T-2 toxin influences brain catecholamines and blood components and thereby possibly brain function in chickens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0032-5791
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-41
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Effects of T-2 toxin on brain catecholamines and selected blood components in growing chickens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.