Linked Life Data

7227344

Source:http://linkedlifedata.com/resource/pubmed/id/7227344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-7-9
pubmed:abstractText
Two morphologic characteristics have been used to define the nonciliated bronchiolar epithelial cell: (1) abundance of agranular endoplasmic reticulum (AER) and (2) numerous membrane-bound ovoid granules. In this study, we examined lobectomy specimens from three nonsmoking humans: one male (9.5 yr) and two females (62 and 43 yr) for comparison with lung specimens from mammalian species used as experimental models in lung research. Following fixation by airway infusion at constant pressure (20 cm), lung tissue was processed by a selective embedding technique and bronchioles of known anatomic location were studied by electron microscopy. Nonciliated bronchiolar epithelial cells of man contained numerous membrane-bound granules (averaging 6 per cell) in the apical cytoplasm and abundant granular endoplasmic reticulum (GER), AER was not observed. Granules averaged 0.3 micrometer in diameter and contained a fine granular matrix and parallel tubular arrays. After comparing these features in man with those of fifteen other species, we concluded that there is a great deal of interspecies variability in the cellular morphology of the nonciliated epithelial cell of distal conducting airways in mammalian lung. Three categories of this cell were observed: (1) with abundant granules and AER, characteristic of rabbit, guinea pig, rat, hamster, mouse, horse, sheep, and pig; (2) with abundant granules of GER, but no AER, characteristic of man and other primates; and (3) with few granules, little AER, and abundant glycogen, characteristic of steer, dog, cat, and ferret.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0190-2148
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Ultrastructure of the nonciliated bronchiolar epithelial (Clara) cell of mammalian lung. III. A study of man with comparison of 15 mammalian species.
pubmed:publicationType
Journal Article, Comparative Study, Case Reports