Linked Life Data

7226974

Source:http://linkedlifedata.com/resource/pubmed/id/7226974

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-7-9
pubmed:abstractText
Dihydrofolate reductases (DHFR) were studied in two groups of trimethoprim (TMP)-resistant Enterobacteria, isolated in Turku, Finland. The first group consisted of six strains with a high level of TMP resistance (MIC greater than 1,000 mg/l) and all of them were found to harbour an additional TMP-insensitive DHFR thought to be responsible for the high degree of resistance. Three Proteus mirabilis strains in this group synthesized chromosomal reductases with reduced TMP sensitivity as well. A second group of six strains, exhibiting MIC values for TMP between 16 and 512 mg/l was seen to be resistant by the production of a chromosomally altered TMP-insensitive DHFR, produced either in normal or slightly elevated amounts. With one exception these strains were all fully susceptible to sulfadiazine and strong synergism with TMP was present. Resistance to nalidixic acid was also frequently observed in this group. In conclusion, three different basic mechanisms were found to be responsible for TMP resistance in Enterobacteria from Finland and these were seen to occur not only independently but also simultaneously in the same strain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0009-3157
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
192-9
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Mechanisms of trimethoprim resistance in enterobacteria isolated in Finland.
pubmed:publicationType
Journal Article