Linked Life Data

722229

Source:http://linkedlifedata.com/resource/pubmed/id/722229

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1979-2-26
pubmed:abstractText
T1Wh (Rb (5;19)1Wh), an albino strain of mice not previously used in the investigation of cleft palate (CP), is homozygous for a (5;19) Robertsonian translocation which provides conspicuous chromosomal markers. Preliminary studies in this laboratory revealed that CP is induced in all the offspring of T1Wh females treated with 2.5 mg of cortisone acetate on days 11-14 of pregnancy and that palatal closure is accomplished at a later morphological and chronological age than in C57BL/6J strain mice. The latter strain had a CP frequency of 42% under similar experimental conditions. Eight- to 16-cell embryos were aggregated in the following combinations: T1Wh in equilibrium T1Wh, C57BL/6J in equilibrium C57BL/6J and T1Wh in equilibrium C57BL/6J. The resulting allophenic blastocysts were transferred to pseudopregnant C57BL/6J recipients which were given the above cortisone treatment and killed on the 18th day of pregnancy. CP was found in all of the 48 T1Wh in equilibrium T1Wh fetuses, 4 (20%) of of 20 C57BL/6J in equilibrium C57BL/6J fetuses and in 17 (26.2%) of 65 T1Wh in equilibrium C57BL/6J fetuses. Analysis of chromosome preparations from the palates of the T1Wh in equilibrium C57BL/6J fetuses demonstrated that there is a positive correlation between the presence of CP and the percentage of susceptible cells in the palate (P less than 0.02). Other data suggest a possible growth advantage in favor of C57BL/6J cells in the palates of T1Wh in equilibrium C57BL/6J allophenic mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-0752
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-77
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Allophenic mice in cleft-palate investigations.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.