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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1981-6-13
|
| pubmed:abstractText |
The role of the Müller cell in the generation of the ERG b-wave was studied in the skate eye by examining the effects of a gliotoxic agent (alpha-aminoadipic acid; alpha-AAA) on retinal structure and function. Superfusing the eyecup for 1 h in 50 mM alpha-AAA resulted in the loss of the b-wave and extensive damage to glial cells, i.e. disruption of the cells' plasma membranes, and a marked loss of cytoplasmic substance. Of the other retinal elements, only the horizontal cells showed some signs of injury in alpha-AAA. On returning the retina to a normal Ringer solution, the widespread loss of cytoplasmic electron density persisted, but the Müller cell membranes appeared to have undergone repair, and the b-wave recovered fully its normal amplitude and waveform.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
307-12
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1981
|
| pubmed:articleTitle |
Changes in ERG b-wave and Müller cell structure induced by alpha-aminoadipic acid.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|