Linked Life Data

7219548

Source:http://linkedlifedata.com/resource/pubmed/id/7219548

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5807
pubmed:dateCreated
1981-6-25
pubmed:abstractText
Chloramphenicol resistance in mammalian cells is cytoplasmically inherited. In yeast, a similar phenotype is caused by mutations in the mitochondrial DNA (mtDNA), and sequencing of carefully constructed strains has identified nucleotide monosubstitutions in the 3' region of the large (21S) rRNA gene which correlate with the antibiotic resistance. We have sequenced the corresponding section of mammalian mtDNA from chloramphenicol-resistant cell lines for comparison with the wild-type sequence. Differences between the sequences occur at positions similar to those altered in the yeast mutants, in a highly conserved region of the large (16S) rRNA gene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
607-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't