Linked Life Data

7217677

Source:http://linkedlifedata.com/resource/pubmed/id/7217677

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-6-13
pubmed:abstractText
Anti-tubular basement membrane antibodies (alpha TBMA) were tested in vitro in an antibody-dependent cellular cytotoxicity (ADCC) reaction utilizing tubular antigen-coated targets. A selected subpopulation of normal guinea pig spleen cells induced significantly more target cell lysis in the presence of sera containing alpha TBMA than in the presence of control sera. this ADCC reaction using alpha TBMA exhibited a characteristic dose responsiveness and the alpha TBMA binding was specific for species-independent tubular antigens. The spleen effector cells used in this assay were characterized as nonadherent, non-T cells bearing Fc-receptors similar to other previously described natural killer cells found in guinea pigs. These studies suggest that natural surveillance systems may be able to use alpha TBMA as an informational bridge to tubular antigens. Such a potential nephritogenic effector mechanism has not been previously described.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1990-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Cell-mediated immunity in interstitial nephritis. IV. Anti-tubular basement membrane antibodies can function in antibody-dependent cellular cytotoxicity reactions: observations on a nephritogenic effector mechanism acting as an informational bridge between the humoral and cellular immune response.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't