Linked Life Data

7216554

Source:http://linkedlifedata.com/resource/pubmed/id/7216554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-6-13
pubmed:abstractText
The relationship between serum and unstimulated and stimulated mixed saliva concentrations of nortriptyline was studied in seven healthy volunteers given a single oral dose of 50 mg. The concentrations were shown to be statistically significantly but variably correlated. The stimulation of saliva flow with Parafilm caused a significant increase in the mean +/- s.e.m. saliva pH from 6.93 +/- 0.15 to 7.34 +/- 0.09 (p less than 0.01). Simultaneously the mean saliva/mean concentration ratio decreased from 0.28 +/- 0.04 to 0.14 +/- 0.03 (p less than 0.001). This decrease correlated significantly with increases in flow rate and pH. Serum concentration could not, however, be reliably calculated from saliva concentrations because of the great variability in the saliva/serum ratios at any given pH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0174-4879
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-81
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Excretion of nortriptyline into saliva.
pubmed:publicationType
Journal Article