Linked Life Data

7215488

Source:http://linkedlifedata.com/resource/pubmed/id/7215488

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1981-6-23
pubmed:abstractText
Small, round photocoagulator lesions of 3-6 degrees (0.6-1.2 mm) diameter were placed nasally on the retina of adult cats. Histological controls proved the complete destruction of all retinal layers within the lesions. Changes in lesion size by shrinkage of the retinal scar did not exceed 0.1 mm or 0.5 degrees. At different times after photocoagulation, single cells were recorded in layers A and A1 of the contralateral lateral geniculate nucleus (LGN) with tungsten microelectrodes. Acute lesions of this size completely deafferented single LGN cells in layer A whose receptive field (RF) area was within the lesion. Thirty days and more after coagulation, light-excitable cells were detected in the originally deafferented LGN region, with RFs in the immediate surround of the retinal lesion. The spontaneous activity and light excitability of these neurons were altered. The representation of 3-4 degrees retinal lesions at 20 degrees horizontal eccentricity was found to be completely filled in by excitation in the LGN. Excitation had spread from the unsevered parts of the retina into the region of deafferentation. Single cells with signs of multiple activation from more than one border region of the retinal lesion were occasionally detected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
256-63
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Time-dependent decrease in the extent of visual deafferentation in the lateral geniculate nucleus of adult cats with small retinal lesions.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't