rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1981-6-23
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pubmed:abstractText |
Kainic acid lesion of rat striata reduces the specific dopamine receptor binding of the butyrophenone antagonist [3H]spiperone and the butyrophenone-like antagonist [3H]domperidone by 56% and 59% respectively. Significantly greater decreases in binding were observed with the agonist [3H]N-propylnorapomorphine (NPA) and the antagonist [3H]flupentixol which showed 79% and 73% losses of high affinity binding respectively. These data indicate that, in part, [3H]spiperone and [3H]domperidone label distinct dopamine receptors with different neuronal localizations from those labeled by [3H]flupentixol and [3H]NPA. Our data is consistent with the hypothesis that [3H]flupentixol and [3H]NPA bind preferentially to adenylate cyclase-linked dopamine (D1) receptors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apomorphine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Domperidone,
http://linkedlifedata.com/resource/pubmed/chemical/Flupenthixol,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/N-n-propylnorapomorphine,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Spiperone
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0014-2999
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7215442-Animals,
pubmed-meshheading:7215442-Apomorphine,
pubmed-meshheading:7215442-Benzimidazoles,
pubmed-meshheading:7215442-Corpus Striatum,
pubmed-meshheading:7215442-Domperidone,
pubmed-meshheading:7215442-Flupenthixol,
pubmed-meshheading:7215442-Kainic Acid,
pubmed-meshheading:7215442-Male,
pubmed-meshheading:7215442-Piperidines,
pubmed-meshheading:7215442-Pyrrolidines,
pubmed-meshheading:7215442-Radioligand Assay,
pubmed-meshheading:7215442-Rats,
pubmed-meshheading:7215442-Receptors, Dopamine,
pubmed-meshheading:7215442-Spiperone
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pubmed:year |
1981
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pubmed:articleTitle |
Kainate lesion dissociates striatal dopamine receptor radioligand binding sites.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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