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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1981-6-25
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pubmed:abstractText |
The effects of the positional isomers of cis-18 : 1 acids on the desaturation of 18 : 2 omega 6 leads to 18 : 3 omega 6 (delta 6 desaturase), 20 : 3 omega 6 leads to 20 : 4 omega 6 (delta 5 desaturase) and 16 : 0 leads to 16 : 1 (delta 9 desaturase) were investigated using essential fatty acid deficient rat liver microsomes. The isomeric cis-18 : 1 acids were found to be inhibitory for the delta 6, delta 5 and delta 9 desaturases, and the position of the double bond is important in determining the degree of inhibition. The effects of the several cis-18 : 1 isomers on delta 6 and delta 5 desaturases were parallel in magnitude exept for the cis-delta isomer which gave 17.5% inhibition for delta 6 desaturase and no inhibition for delta 5 desaturase. The strongest inhibitor for delta 6 desaturase (cis-delta 8 18 : 1) was also the most potent inhibitor for delta 5 desaturase, and the weakest inhibitor for delta 6 desaturase (cis-delta 3 18 : 1) was the least effective inhibitor on delta 5 desaturase. The delta 9 desaturase was maximally inhibited by cis-delta 10 and delta 11 18 : 1 isomers. The cis-18 : 1 acid isomers in partially hydrogenated edible fats may have effects on the lipid metabolism through their inhibitory effects on the desaturases.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8,11,14-Eicosatrienoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Acyl Coenzyme A,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid Desaturases,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Oleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitoyl Coenzyme A,
http://linkedlifedata.com/resource/pubmed/chemical/linoleoyl-coenzyme A
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
663
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
58-68
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7213772-8,11,14-Eicosatrienoic Acid,
pubmed-meshheading:7213772-Acyl Coenzyme A,
pubmed-meshheading:7213772-Animals,
pubmed-meshheading:7213772-Fatty Acid Desaturases,
pubmed-meshheading:7213772-Fatty Acids, Unsaturated,
pubmed-meshheading:7213772-Isomerism,
pubmed-meshheading:7213772-Kinetics,
pubmed-meshheading:7213772-Linoleic Acids,
pubmed-meshheading:7213772-Microsomes, Liver,
pubmed-meshheading:7213772-Oleic Acids,
pubmed-meshheading:7213772-Palmitic Acids,
pubmed-meshheading:7213772-Palmitoyl Coenzyme A,
pubmed-meshheading:7213772-Rats,
pubmed-meshheading:7213772-Structure-Activity Relationship,
pubmed-meshheading:7213772-Substrate Specificity
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pubmed:year |
1981
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pubmed:articleTitle |
Inhibition of desaturation of palmitic, linoleic and eicosa-8,11,14-trienoic acids in vitro by isomeric cis-octadecenoic acids.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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