Linked Life Data

7212248

Source:http://linkedlifedata.com/resource/pubmed/id/7212248

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1981-5-13
pubmed:abstractText
The pharmacokinetic behaviour of etomidate was investigated in 7 patients. A method for the analysis of etomidate is described using gas-liquid chromatography for separation and alkali flame ionization detection. The lower limit of detection for etomidate in plasma was 0.005 microgram/ml. The pharmacokinetic behaviour of etomidate after an intravenous bolus injection of 20 mg may be described in terms of an open two-compartment model. The plasma half-life of etomidate was in the alpha-phase about 3 minutes, the biological half-life of the beta-phase was about 70 minutes. The total volume of distribution was calculated at 165 litres. The total plasma clearance amounted to 1600 ml/min. These pharmacokinetic data were used to establish an intravenous infusion scheme for etomidate.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-2417
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
658-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
[Pharmacokinetics of etomidate in man (author's transl)].
pubmed:publicationType
Journal Article, English Abstract