Linked Life Data

7205889

Source:http://linkedlifedata.com/resource/pubmed/id/7205889

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-5-26
pubmed:abstractText
The synthesis and the biological activities of [asparagine]angiotensin II analogues with alkyl-substituted amide groups are reported. This study was performed in order to elucidate further the importance and the influence of the side chain in position 1 of angiotensin II. The two synthesized analogues [1-(N4,N4-dipropyl)asparagine]- and [1-(N4,N4-diisopropyl)asparagine]angiotensin II were compared to [1-asparagine]angiotensin II (hypertensin, Ciba) and to [1-(N4,N4-dimethyl)asparagine]angiotensin II in vitro and in vivo. All compounds had full intrinsic activity, but their potency decreased with increasing alkyl size of the substituted carboxamide group. Despite their reduced potency, the alkylated analogues showed enhanced duration of action on rabbit aorta strips. The relative potencies of the series hypertensin, dimethyl, dipropyl, and diisopropyl analogues on rabbit aorta strips were 100, 46, 16, and 9%, respectively. In the rat blood pressure assay they were 100, 30, 9, and 7%, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Studies on position 1 of angiotensin II: effects on affinity and duration of action from alkyl amide substitution.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't