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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1981-5-26
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pubmed:abstractText |
alpha-Ethynyl- and alpha-vinylornithine were designed and synthesized as potential enzyme-activated inhibitors of mammalian ornithine decarboxylase. These two new inhibitors produce both immediate and time-dependent inhibition of rat liver ornithine decarboxylase in vitro. The inhibitions exhibition saturation kinetics. The apparent dissociation constants (KI) are 10 and 810 microM, and the times of half-inactivation at infinite concentration of inhibitor (t1/2) are 8.5 and 27 min, respectively, for alpha-ethynyl- and alpha-vinylornithine. In rats, alpha-ethynylornithine causes a rapid dose-dependent decrease of ornithine decarboxylase activity in prostate and, to a lesser extent, in thymus and testis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16-20
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7205870-Animals,
pubmed-meshheading:7205870-Carboxy-Lyases,
pubmed-meshheading:7205870-Chemical Phenomena,
pubmed-meshheading:7205870-Chemistry,
pubmed-meshheading:7205870-Enzyme Activation,
pubmed-meshheading:7205870-Kinetics,
pubmed-meshheading:7205870-Liver,
pubmed-meshheading:7205870-Male,
pubmed-meshheading:7205870-Ornithine,
pubmed-meshheading:7205870-Ornithine Decarboxylase,
pubmed-meshheading:7205870-Rats
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pubmed:year |
1981
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pubmed:articleTitle |
alpha-Ethynyl and alpha-vinyl analogues of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase.
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pubmed:publicationType |
Journal Article,
In Vitro
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