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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1981-5-21
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pubmed:abstractText |
Circulating immune complexes were isolated by 2% polyethylene glycol precipitation from the sera of 15 out of 37 patients with Behçet's syndrome and 11 out of 23 patients with recurrent oral ulcers. The antigenic cross-reactions of the polyethylene glycol precipitates were studied by coating a plastic tube with one complex and adding another 125I-labeled complex in dissociating (acid) conditions. On neutralization, partial reassembly occurred with the complex coating the tube wall, thus indicating cross-reaction with it. In the first 30 complexes studied, the cross-reactions obtained were sorted by computer program into two mutually exclusive subsets of reactions. Two similar homologous subsets of reactions were found in the second group of 29 patients: in total, nine out of 16 ocular, four out of six herpetiform circulating immune complexes in one subset, and four out of seven neurological in the other. A wider pattern of reaction could be detected in addition, which induced most of the Behçet's syndrome and recurrent oral ulcers. Immune complexes from control sera did not cross-react. An exogenous agent could account for the circulating immune complexes' cross-reactions for the group as a whole, and two antigenic determinants of that agent or antigens from different damaged tissues explain the subsets.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
pubmed:issn |
0022-2143
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
97
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
559-67
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7205064-Antigen-Antibody Complex,
pubmed-meshheading:7205064-Behcet Syndrome,
pubmed-meshheading:7205064-Computers,
pubmed-meshheading:7205064-Cross Reactions,
pubmed-meshheading:7205064-Humans,
pubmed-meshheading:7205064-Polyethylene Glycols,
pubmed-meshheading:7205064-Recurrence,
pubmed-meshheading:7205064-Stomatitis, Aphthous
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pubmed:year |
1981
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pubmed:articleTitle |
Different cross-reacting circulating immune complexes in Behçet's syndrome and recurrent oral ulcers.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|