Linked Life Data

7202513

Source:http://linkedlifedata.com/resource/pubmed/id/7202513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-5-21
pubmed:abstractText
The adenine nucleotide ATP relaxed the tracheal strip of the guinea pig, while the methylene isosteres of ATP, alpha, beta-methylene ATP (APCPP) and beta, gamma-methylene ATP (APPCP) in concentrations up to 100 micrograms were either inactive or produced a small contraction. The relaxation of the tracheal strip elicited by ATP was completely abolished by treatment of the tissue with indomethacin, a prostaglandin synthesis inhibitor. The relaxations induced by ATP in the guinea-pig taenia coli were followed by a rebound contraction which could be blocked by indomethacin. The two methylene analogues of ATP, produced relaxations in the taenia coli which were not followed by a rebound contraction. It is concluded that in the guinea-pig tracheal chain and taenia coli preparations ATP stimulated prostaglandin synthesis while the analogues modified in the polyphosphate chain were unable to do so.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The structural conformation of the polyphosphate chain of the ATP molecule is critical for its promotion of prostaglandin biosynthesis.
pubmed:publicationType
Journal Article, In Vitro