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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1981-5-26
|
| pubmed:abstractText |
Black widow spider venom (BWSV) elicited a prolonged tonic contraction of guinea-pig ileum which abolished the nicotine-induced contraction; however, the subsequent acetylcholine stimulation was found to be unchanged. These findings indicate a depletion of nerve terminal transmitters caused by BWSV without a disruption of the muscle contractile mechanism. Following the BWSV-induced contraction, the stimulation to 5-hydroxytryptamine (5-HT) was found to be abolished. This abolishment indicates a mediation of 5-HT-induced smooth muscle contraction in the nerve rather than the muscle.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
19
|
| pubmed:volume |
68
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
497-500
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7202505-Animals,
pubmed-meshheading:7202505-Arthropod Venoms,
pubmed-meshheading:7202505-Black Widow Spider,
pubmed-meshheading:7202505-Guinea Pigs,
pubmed-meshheading:7202505-Male,
pubmed-meshheading:7202505-Muscle, Smooth,
pubmed-meshheading:7202505-Muscle Contraction,
pubmed-meshheading:7202505-Serotonin Antagonists,
pubmed-meshheading:7202505-Spider Venoms,
pubmed-meshheading:7202505-Spiders
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
Inhibition of 5-hydroxytryptamine contraction of guinea-pig smooth muscle treated with black widow spider venom.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.
|