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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1981-5-28
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pubmed:abstractText |
Ethanol, in a concentration of 40--160 mM, depressed the electrically evoked contractions of the guinea-pig ileum longitudinal muscle/myenteric plexus (LM/MP) preparation in a dose-dependent manner. The acute ethanol inhibition in vitro was partially reversed by raising the extracellular calcium concentration. Following a 4 week ethanol treatment in vivo, by means of daily i.p. injections, the LM/MP preparation was rendered tolerant to ethanol and at the same time calcium was more effective in reversing the inhibitory effect of ethanol. It appears that calcium plays a role in the acute action of, and development of tolerance to, ethanol.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
21
|
pubmed:volume |
68
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
223-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7202488-Animals,
pubmed-meshheading:7202488-Calcium,
pubmed-meshheading:7202488-Dose-Response Relationship, Drug,
pubmed-meshheading:7202488-Drug Tolerance,
pubmed-meshheading:7202488-Ethanol,
pubmed-meshheading:7202488-Guinea Pigs,
pubmed-meshheading:7202488-Male,
pubmed-meshheading:7202488-Muscle Contraction,
pubmed-meshheading:7202488-Neuromuscular Junction
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pubmed:year |
1980
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pubmed:articleTitle |
A role for calcium in the acute and chronic actions of ethanol in vitro.
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pubmed:publicationType |
Journal Article,
In Vitro
|