Linked Life Data

7202096

Source:http://linkedlifedata.com/resource/pubmed/id/7202096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
25
pubmed:dateCreated
1982-10-29
pubmed:abstractText
Rats with large lesions of the superior colliculus do not display the oral stereotypy normally induced by high systemic doses of dopamine-agonists. It has been suggested that collicular lesions have such an effect because they destroy the GABAergic nigrotectal pathway. This suggestion was investigated by observing the effects of bilateral microinjections of the GABA-agonist muscimol into midbrain sites in rats given 8 mg/kg subcutaneous apomorphine. A low dose of muscimol (25 ng in 0.5 ul saline/side) injected into regions of the superior colliculus with nigrotectal innervation almost abolished apomorphine-induced licking and gnawing. Control microinjections of saline into the superior colliculus, or of muscimol into overlying cerebral cortex, were ineffective. This result is consistent with the GABAergic nigrotectal projection being important for the expression of dopamine-related oral stereotypy. It was also found, however, that 25 ng of muscimol suppressed oral stereotypy when microinjected into the mesencephalic reticular formation underlying the superior colliculus. The anatomical basis of this latter effect is uncertain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2171-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Suppression of apomorphine-induced oral stereotypy in rats by microinjection of muscimol into midbrain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't