Linked Life Data

7201813

Source:http://linkedlifedata.com/resource/pubmed/id/7201813

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-9-10
pubmed:abstractText
In a comparative study on the pharmacokinetics of two paracetamol suppository preparations (A = Kinder-Tylenol, B = reference compound as a commercial preparation), serum levels were determined in 10 healthy male volunteers between 23 and 32 years over 12 h at 11 measurement points. Aim of the trial was to examine the bioavailability, the absorption and elimination rate as well as the distribution volume for both preparations. After application of both suppository preparations the serum levels revealed that the absorption from prep. A was more than twice as fast (k1 = 0.762 h-1) as that from prep. B (k1 = 0.348 h-1), resulting in an obviously higher maximum blood level. The bioavailability values are also higher when prep. A is administered (123% versus prep. B).
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
420-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[On the pharmacokinetics and bioavailability of paracetamol in suppositories for paediatry (author's transl)].
pubmed:publicationType
Journal Article, English Abstract