| pubmed-article:7201258 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0016564 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0025688 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0027310 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C1979928 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0597526 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C0677517 | lld:lifeskim |
| pubmed-article:7201258 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:7201258 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7201258 | pubmed:dateCreated | 1982-8-7 | lld:pubmed |
| pubmed-article:7201258 | pubmed:abstractText | In order to characterize further the in vitro liver microsomal O-demethylation and defluorination of the volatile anesthetic methoxyflurane, and obtain additional information regarding the participation of cytochrome P-450 in the oxidation, the stoichiometry of the reaction was determined and the effect of antibody to cytochrome P-450 reductase on this unique biotransformation was examined. Liver microsomes were isolated from rabbits and rats in which enzyme induction had previously been produced by phenobarbital. The O-demethylation of methoxyflurane by phenobarbital-induced microsomes results in the production of 1 mol of formaldehyde for every 2 mol of fluoride ion produced. Dichloroacetic acid is also a product of methoxyflurane O-demethylation. Antibody to cytochrome P-450 reductase inhibits by 85% the amount of fluoride ion produced by the microsomal metabolism of methoxyflurane. Thus critical indirect supportive data are contributed to the hypothesis that at least one, but perhaps more, cytochrome P-450 is indeed responsible for methoxyflurane O-demethylation and defluorination. | lld:pubmed |
| pubmed-article:7201258 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7201258 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7201258 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7201258 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7201258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7201258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7201258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7201258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7201258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7201258 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7201258 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7201258 | pubmed:issn | 0003-2999 | lld:pubmed |
| pubmed-article:7201258 | pubmed:author | pubmed-author:GonzalezSS | lld:pubmed |
| pubmed-article:7201258 | pubmed:author | pubmed-author:WaskellLL | lld:pubmed |
| pubmed-article:7201258 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7201258 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:7201258 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7201258 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7201258 | pubmed:pagination | 609-13 | lld:pubmed |
| pubmed-article:7201258 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:meshHeading | pubmed-meshheading:7201258-... | lld:pubmed |
| pubmed-article:7201258 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7201258 | pubmed:articleTitle | Dependence of microsomal methoxyflurane O-demethylation on cytochrome P-450 reductase and the stoichiometry of fluoride ion and formaldehyde release. | lld:pubmed |
| pubmed-article:7201258 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7201258 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7201258 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7201258 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
