Linked Life Data

7200970

Source:http://linkedlifedata.com/resource/pubmed/id/7200970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-8-26
pubmed:abstractText
Pulmonary removal of [3H]prostaglandin E1 ([3H]PGE1) was measured by double indicator-dilution techniques after bolus injections of indocyanine green and trace amounts of [3H]PGE1 before and after 1-3 h of total cardiopulmonary bypass (CPB) or 3 h of left-heart bypass (LHB) in 18 anesthetized dogs. Before bypass, pulmonary removal was 85.7 +/- 1.2% (means +/- SE, n = 18) and was unchanged on restoration of normal circulation after 1-2 h of CPB (80.6 +/- 1.8%, n = 7) or 3 h of LHB (87.4 +/- 1.6%, n = 4). However, on restoration of normal pulmonary arterial blood flow after 3 h of CPB, removal was significantly decreased to 74.5 +/- 2.2% (P less than 0.01, n = 7). Postbypass depression of [3H]PGE1 removal may explain our previous observations that intrabypass elevations in endogenous immunoreactive prostaglandin E in dogs were not entirely reversible on cessation of 3-4 h of CPB. Possible factors underlying depression of post-CPB pulmonary removal of [3H]PGE1 include: 1) local saturation of [3H]PGE1 removal secondary to intrapulmonary or intravascular release of prostaglandin E, 2) inhibition of prostaglandin dehydrogenase activity, or 3) damage to endothelial cell transport of [3H]PGE1 from the pulmonary microcirculation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0161-7567
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
887-92
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Depressed pulmonary removal of [3H]prostaglandin E1 after prolonged cardiopulmonary bypass.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.