Linked Life Data

7200612

Source:http://linkedlifedata.com/resource/pubmed/id/7200612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-7-8
pubmed:abstractText
The single and combined effects of acute phencyclidine (PCP) and propranolol, each given intraperitoneally, were studied on rat behavior. PCP (5, 10, 25, 50, and 100 mg/kg) produced dose-related stereotypy and increases in (photocell) hyperactivity over 4 h observation. Propranolol (10 and 25 mg/kg) neither caused any stereotypy nor had any effect on activity relative to vehicle control. Additionally, propranolol (10 and 25 mg/kg), given 30 min after PCP (10, 25 and 50 mg/kg), reduced or completely blocked the stereotypy and hyperactivity caused by PCP. These data provide the first experimental verification of a clinical observation that propranolol may be an effective antagonist of the behavioral toxicity produced by PCP.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-7012
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-104
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Propranolol antagonizes phencyclidine-induced hyperactivity and stereotypy in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.