Linked Life Data

7199735

Source:http://linkedlifedata.com/resource/pubmed/id/7199735

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-5-21
pubmed:abstractText
The psychopharmacological profile and mechanism of action of ten atypical novel and potential antidepressive drugs (AD) have been investigated. It has been shown that they form a pharmacologically heterogeneous group. Some of them may be considered as central 5-hydroxytryptamine (5-HT) antagonists. Two typical AD, amitriptyline and doxeprine, turned out to be potent 5-HT antagonists also. These observations justify the conclusion that these drugs rather block than facilitate 5-HT neurotransmission. Some data indicate that 5-HT antagonists can shift the balance between the noradrenergic and serotoninergic systems in favour of the former. Both atypical and typical AD when administered chronically, induce effects not observed after single-dose treatment. The effects observed indicate that the chronic administration of AD leads to the development of the increased responsiveness (or activation) of the noradrenergic system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0720-4280
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
26-30
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Atypical antidepressant drugs - psychopharmacological profile and mechanism of action.
pubmed:publicationType
Journal Article