Linked Life Data

7199341

Source:http://linkedlifedata.com/resource/pubmed/id/7199341

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-4-22
pubmed:abstractText
Gyromitrin, the main poison of the false morel Gyromitra esculenta, causes enlargement of the liver in rats. The content of triglycerides and total cholesterol were increased in the liver homogenate and microsomal fraction but not in the mitochondrial fraction. On the other hand the content of phospholipids was found to be decreased. The enhanced incorporation of [14c]-acetate into the lipids of rat livers after gyromitrin indicates an increased rate of lipids synthesis. The diminution of the phospholipids is caused mainly by a loss of phosphatidyl ethanolamine (PE) although after a short pulse with [14C]-ethanolamine the specific radioactivity of the isolated phosphatidyl ethanolamine corresponded to that of the controls. Since the content of phosphatidylcholine (PC) remained unchanged, the PC/PE-ratio was shifted from 2.3 to 4.5. These effects were reversible within 48 h. Inhibition of the synthesis of highly unsaturated fatty acids by the microsomal monoxygenase system is discussed as the primary reason for the above observations this inhibition possibly being due to active metabolites of gyromitrin which destroy the monoxygenases.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-63
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Influence of the mushroom poison gyromitrin on the lipids of rat liver (author's transl)].
pubmed:publicationType
Journal Article, English Abstract