Linked Life Data

7199324

Source:http://linkedlifedata.com/resource/pubmed/id/7199324

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12a
pubmed:dateCreated
1982-4-22
pubmed:abstractText
After oral dosing of 10 mg 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4] benzodiazepine (midazolam, Ro 21-3981, Dormicum) labelled with 14C (25 microCi) to 4 human volunteers, the total radioactivity is mainly excreted via the kidneys. Nearly 90% are excreted within 24 h. Main urinary metabolite is the conjugated 1-hydroxymethyl derivative, which amounts to 60-70% of the administered dose within 24 h. Compared to total radioactivity, levels of unchanged drug in plasma are rather low and differ from one subject to the next. Most of the plasma radioactivity consists of the 1-hydroxymethyl compound, most of it in conjugated form. Levels of free metabolite are lower than those of unchanged drug. Radioactivity is rapidly eliminated from plasma. The results of the present oral study seem to indicate significant first-pass metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2220-3
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Excretion and metabolism of 14C-midazolam in humans following oral dosing.
pubmed:publicationType
Journal Article