Linked Life Data

7198471

Source:http://linkedlifedata.com/resource/pubmed/id/7198471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1982-2-12
pubmed:abstractText
In anesthetized dogs, (+)-(R)-alpha ((S)-1-[(3,3-di-3-thienylallyl)amino]-ethyl)-benzylalcohol hydrochloride (tinofedrine hydrochloride, D 8955) causes a remarkable increase of cardiac output by positive inotropic and chronotropic stimulation of the heart and simultaneous reduction of peripheral vascular resistance. The effect is antagonized by beta-adrenergic blocking drugs. In comparison with typical beta-agonists (e.g., orciprenaline) tinofedrine at inotropically equieffective doses, has a much weaker effect on the heart rate. Measurement of tissue blood flow by radioactive tracer microspheres after tinofedrine exhibited a rather homogeneous increased perfusion in all parts of the brain, as well as myocardium, kidneys and liver. In coronary circulation tinofedrine causes vasodilation so that in a therapeutic dose range increased work load is equalized by a sufficient myocardial supply. Tinofedrine itself neither caused a disturbance of heart rhythm nor worsened aconitine-induced arrhythmias in anesthetized rats. Simultaneous application of digoxin or diazepam did not influence the action of tinofedrine; there was no evidence of any incompatibility of such combinations. Experiments with a possible metabolite (l-norephedrine) showed that it is not involved in the action of tinofedrine.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1892-902
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Investigations on the general effects of tinofedrine on heart and blood circulation (author's transl)].
pubmed:publicationType
Journal Article, English Abstract