Linked Life Data

7198165

Source:http://linkedlifedata.com/resource/pubmed/id/7198165

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-2-12
pubmed:abstractText
Inflammatory processes on the hepato-biliary system may play an important role in the pathogenesis of infantile obstructive cholangiopathy (including biliary atresia, neonatal hepatitis and bile duct dilatation). A model of the disease was produced in rats using 1,4-phenylenediisothiocyanate (P.D.T.) P.D.T. was given to five groups of rats of different developmental stages from the fetal stage. Changes in the hepato-biliary system due to P.D.T. were compared histo-pathologically in 97 rats. Three groups of rats given P.D.T. after birth showed characteristic dilatation of the extrahepatic bile ducts with inflammation. One group of rats given P.D.T. during the fetal period showed thickening and fibrosis of the wall of the extrahepatic bile ducts without dilatation. The last group of rats given P.D.T. during the fetal period and again at thirty days postnatally showed stenosis or almost atresia of the ductal lumen due to severe fibrosis and thickening of the extrahepatic bile ducts. This experimental model suggests that the difference in developmental stages of the pathogenic processes may play an important role in the production of different pathogenic features of infantile obstructive cholangiopathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0047-1909
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
372-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Experimental model of infantile obstructive cholangiopathy using 1,4-phenylenediisothiocyanate.
pubmed:publicationType
Journal Article