Linked Life Data

7196751

Source:http://linkedlifedata.com/resource/pubmed/id/7196751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1981-10-25
pubmed:abstractText
Newly calculated increments of molar volumes and surface areas were compared with hydrophobic fragmental constants in an effort to establish a relationship between these parameters. For completely non-polar fragments, the hydrophobicity is directly and linearly related to the volume or surface area. In the case of most fragments, however, the hydrophobicity is found to result from two factors, namely, a) a volume- or surface-related lipophilicity, and b) a lipophobicity effect, designated. The physical meaning of this parameter is unclear at present and may be related to hydration effects. The parameter may be of interest in QSAR studies. This is illustrated by an example in which the combined use of V and discriminates between the steric and lipophobic contributions of the partition coefficient to the biological activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1053-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Steric and lipophobic components of the hydrophobic fragmental constant.
pubmed:publicationType
Journal Article