Linked Life Data

7195927

Source:http://linkedlifedata.com/resource/pubmed/id/7195927

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-9-25
pubmed:abstractText
Discrete patches of spongiform degeneration have been found in the cerebral cortex of three rats, 28 and 30 months of age. Many of these patches have in their midst a central nonvacuolated region containing a star-shaped homogeneous core. Using Congo red stain, there is evidence for the presence of amyloid in this core. In the electron microscope, this central region is seen to be composed of degenerating and abnormal neuronal processes, reactive neuroglia, and extracellular filamentous material with the fine structural characteristics of amyloid. Microglial cells are uniquely modified to accommodate bundles of these extracellular filaments, which are often contained in furrows that deeply invaginate the surfaces of these cells. On the basis of its three main constituents, the central region is considered to be a form of neuritic plaque. The large complex clearings in the vacuolar region of each lesion appear to be formed by the coalescence of smaller vacuoles in the surrounding neuropil.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
472-87
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The structure of neuritic plaque in the cerebral cortex of aged rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.