Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-6-25
pubmed:abstractText
The highly purified uricase from Candida utilis was modified with 2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine (activated PEG2), which was synthesized from monomethoxypolyethylene glycol (MW 5,000) and cyanuric chloride. Modification of approximately 36 out of the total 98 amino groups in the uricase molecule led to the complete loss of the binding ability towards antiuricase serum from rabbit with the retention of high enzymic activity (45% of native uricase). The modified uricale cleared more slowly from the plasma of mice compared with native uricase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0013-9432
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-53
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Improved modification of yeast uricase with polyethylene glycol, accompanied with nonimmunoreactivity towards anti-uricase serum and high enzymic activity.
pubmed:publicationType
Journal Article