Linked Life Data

7193465

Source:http://linkedlifedata.com/resource/pubmed/id/7193465

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-5-28
pubmed:abstractText
1. The effect of [K]0 on the current-voltage relationship is described. In the negative potential range the curves cross over as [K]0 is increased. At positive potentials the curves re-cross so that in low [K]0 there is more outward current than in high [K]0. 2. Chord conductance has been calculated from the current-voltage relationship and this is taken as a measure of gK. It is shown gK is a function of both the potassium driving force (EM--EK) and [K]0. 3. Current-voltage relationships obtained by the voltage clamp technique have been compared to net current-voltage relationships obtained by phase plane analysis of the action potential. [K]0 is shown to have similar effects on both. 4. The effect of [K]0 at positive potentials suggests that delayed outward current during large depolarizing voltage clamp steps is due to an activation of a time-dependent outward current and not to potassium accumulation. An analysis of current tails also suggests the presence of a time-dependent outward current. 5. In contrast delayed outward current changes during small depolarizing voltage clamp steps are probably due to potassium accumulation. 6. Evidence is presented which indicates that inward current tails following depolarizing voltage clamp steps are due to potassium accumulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
389
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Cow ventricular muscle. I. The effect of the extracellular potassium concentration on the current-voltage relationship. II. Evidence for a time-dependent outward current.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't