Linked Life Data

7192626

Source:http://linkedlifedata.com/resource/pubmed/id/7192626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-3-24
pubmed:abstractText
It has been observed that a dolichol, alpha dihydro-undecaprenol, induces phenotypic changes in Ehrlich ascites tumour [EAT] cells. In the presence of this dolichol in the medium. EAT cells attach to glass and spread on it but grow in an overlapping pattern. This spreading takes place after a lag of between 72-96 hours at continuous exposure to the dolichol. When cells, once induced to spread, are trypsinized, they can spread once more within 3-6 hours in the dolichol-free medium. It is suggested that dolichols, which act as lipid intermediates in protein glycosylation, may represent a class of compounds which by interference with the biosynthesis of plasma membrane constituents influence surface properties of EAT cells and induce spreading. The results presented in this paper support the view that sugar moieties of plasma membrane constituents play a role in controlling cell attachment, spreading, and intercellular communication.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0171-9335
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-43
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Induction of an attachment and spreading on glass of Ehrlich ascites tumour cells by alpha-saturated polyprenols.
pubmed:publicationType
Journal Article