Linked Life Data

7192358

Source:http://linkedlifedata.com/resource/pubmed/id/7192358

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-2-19
pubmed:abstractText
The effect of inhibitors of microsomal cytochrome P-450 on endogenous respiration and the redox state of components in the electron transport chain was studied in the cells of Torulopsis candida. SKP-525 A and methyrapone in the presence of preliminarily added cyanide (or antimycin A) almost completely inhibited endogenous respiration of the cells irrespective of the growth phase of the culture. The effect of these inhibitors on endogenous respiration and the reduction state of pyridine nucleotides, flavoproteins and cytochromes b, c and a + a3, at all of the studied growth phases, was similar to that of hydroxamic acids, the inhibitors of the mitochondrial alternative oxidase system. Contrary to their action on endogenous respiration of the cells at the exponential phase, both benzhydroxamic acid (BHA) and the inhibitors of microsomal hydroxylation, in the presence of rotenone, suppressed endogenous respiration of the cells taken at the stationary phase. Therefore, the interaction of the electron transport chains changed in the process of the cultural growth. Addition of BHA to the medium inhibited growth of the culture on glucose and biosynthesis of cytochrome P-450 in these cells. The culture did not grow on hexadecane in the presence of BHA. Apparently, hydroxamic acids can affect the operation of the microsomal monooxigenase system containing cytochrome P-450.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0026-3656
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
664-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Effect of inhibitors of microsomal hydroxylation on endogenous respiration of Torulopsis candida cells].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract