Linked Life Data

719187

Source:http://linkedlifedata.com/resource/pubmed/id/719187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1979-2-23
pubmed:abstractText
Chronic exposure of human skin to solar irradiation results in a variety of preneoplastic and frankly neoplastic skin lesions. We have shown that in solar keratoses (SK) and in paralesional skin there is instead of an even distribution of succinic dehydrogenase (SDH) activity a relative decreased activity in the granular cell layer. Furthermore, there is enhancement of the usual concentration of glucose-6-phosphate dehydrogenase (G6PDH) activity in the granular zone as well as an increase in total G6PDH epidermal activity. In the experimental part of this study, six normal volunteer subjects had areas of normally non exposed skin (buttocks) irradiated with a 2 Mean erythema dose of ultra violet light (290--400 nm) on between 3 and 5 occasions per week for 2--6 week periods. The results obtained indicated that the same changes in enzyme activity localization take place in artificially irradiated normally non exposed epidermis as seen in normally exposed skin nearby actinic keratoses. It is suggested that these quantitative changes may be the basis of a model for the study of chronic ultra violet light damage to the epidermis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0007-4551
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
351-6
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Quantitative changes in respiratory enzyme activity in premalignant lesions and experimentally irradiated skin.
pubmed:publicationType
Journal Article