Linked Life Data

7190617

Source:http://linkedlifedata.com/resource/pubmed/id/7190617

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1980-10-21
pubmed:abstractText
o-Nitrobenzyl and p-nitrobenzyl alcohols, halides, and N-substituted carbamates were prepared as potential bioreductive alkylating agents, and first half-wave reduction potentials of these compounds were measured by differential pulse polarography. The cytotoxicities of these agents were examined by determining the colony-forming ability of EMT6 tumor cells following exposure to each agent at concentrations of 0.01 to 500 microM for 1 h at 37 degrees C under conditions of normal aeration and chronic hypoxia. The o-nitrobenzyl compounds were significantly more cytotoxic to hypoxic cells than to oxygenated cells. This selective cytotoxicity is hypothesized to result from alkylation following more efficacious bioreductive activation of these compounds by hypoxic cells. Nitrobenzyl compounds with such selective toxicity to hypoxic neoplastic cells may prove to be particularly valuable in combination therapy designed for the treatment of solid tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
955-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Nitrobenzyl halides and carbamates as prototype bioreductive alkylating agents.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.