Linked Life Data

7189951

Source:http://linkedlifedata.com/resource/pubmed/id/7189951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1980-8-25
pubmed:abstractText
Pyridine inhibited the conversion of PG endoperoxide to TXA2 catalyzed by TX synthetase from human platelet and swine lung microsomes. The inhibitory potency of pyridine is abolished by derivatizing pyridine at the 2-position but is increased by introducing hydrophobic substituents at 3- or 4-positions, with 3-substituted pyridines being the most potent inhibitors. Inhibition by pyridine and its derivatives was also selective, since other enzymes in the arachidonic acid cascade were not significantly affected. Pyridine and the active derivatives also inhibited human platelet aggregation induced by arachidonic acid or ADP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-5952
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
447-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Inhibition of thromboxane synthesis and platelet aggregation by pyridine and its derivatives.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.