Linked Life Data

7189027

Source:http://linkedlifedata.com/resource/pubmed/id/7189027

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-5-14
pubmed:abstractText
Previous electron spin resonance studies in myotonic muscular dystrophy (MyMD) have suggested that an increased cell surface membrane "fluidity" might underlie the widespread abnormalities in this disorder. We attempted to confirm and expand those findings by using another physical probe technique: fluorescence polarization spectroscopy. Spectral characteristics and rotational relaxation rates of four hydrophobic fluorescent probes were monitored in control and MyMD erythrocyte membrane ghosts. Structural unrelated probes were used to minimize the possibility that an alteration in physical properties in a restricted membrane microdomain would pass undetected. All probes were studied between 5 degrees C and 40 degrees C in each preparation to quantitate temperature-dependent changes. We failed to confirm the abnormality in apparent membrane fluidity previously reported in MyMD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0028-3878
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Fluorescent probe analysis of erythrocyte membranes in myotonic dystrophy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.