Linked Life Data

7188444

Source:http://linkedlifedata.com/resource/pubmed/id/7188444

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-9-20
pubmed:abstractText
The present study was based upon the assumption that the efficacy of tumor treatment depends not only on the response of malignant cells to a given drug but on local oxygen tension as well as on number and alignment of capillaries. Transparent chambers were implanted in the dorsal skin flap of 32 Syrian (Gold) hamsters. Permanent indwelling catheters in carotid artery and jugular vein served for measuring the systemic pressures and heart rate; 48 hours later, 4 X 10(4) cells of the amelanotic melanoma A-Mel-3 were transplanted (16 animals) s.c. in the area exposed for daily intravital microscopy. A platinum multiwire electrode and quantitative video techniques were utilized for measurements of local PO2 and capillary blood flow. Capillary density, capillary diameter and surface area were analyzed throughout the vascularized melanoma during the first 12 days of growth. When compared to controls (16 animals) and tissue in the immediate neighborhood of the tumor, mean local PO2 on the tumor's surface decreased with tumor size. Capillary density of the melanoma was elevated 4 days after tumor inoculation but decreased significantly until day 12. As a result of enhanced capillary diameters, capillary surface area increased eight-fold during earliest growth of the melanoma. Of hemodynamic significance were huge platelet conglomerates consistently noted in short, dilated capillaries at the melanoma edge. As a consequence, the number of erythrocyte perfused capillaries decreased with tumor growth and 38% and 50% of the arterial inflow was bypassing the capillary network 8 and 12 days after tumor inoculation. These data indicate that due to rarefication of capillaries, the full impact of tumor treatment is diminished by an elevated microvascular resistance which could significantly affect the therapy of the melanoma. On the basis of these studies it is concluded that improvement of the blood's fluidity might result in a better response to adjuvant chemotherapy of the melanoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0167-6865
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-99
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Distribution of microflow and oxygen tension in hamster melanoma.
pubmed:publicationType
Journal Article