Linked Life Data

7187774

Source:http://linkedlifedata.com/resource/pubmed/id/7187774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1984-3-20
pubmed:abstractText
Intraamnial administration of isoproterenol (IPRO) to chick embryo induces different types of pathological changes of the myocardial and liver tissue: their character depends upon the developmental period during which the drug was administered. Analysis of the embryotoxic effect of IPRO has revealed that the time-course of in vivo uptake of [3H]IPRO by the developing heart appears to present the same pattern as the embryonic liver tissue; both peak values (10 min and 6 h after injection) were, however, significantly higher in the liver as compared with the myocardium. IPRO is rapidly metabolized to 3-o-methyl-IPRO; the proportion of this fraction in both organs represents approximately 40% of total radioactivity as early as 5 min after administration. Intraamnial administration of IPRO significantly increases the cAMP content in the myocardium; dibutyryl cAMP-induced myocardial lesions occurred, however, only occasionally and in comparison with IPRO they were significantly less pronounced. The cardiotoxic effect of IPRO can be significantly reduced by beta-blockade; calcium antagonist, verapamil, was found to have no protective effect. Our results suggest that the following factors may participate in the IPRO-induced embryotoxicity: (1) IPRO, (2) its toxic metabolites, (3) cAMP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-7948
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
867-9
pubmed:dateRevised
2006-7-19
pubmed:meshHeading
pubmed:articleTitle
Analysis of the cardiotoxic effect of isoproterenol in chick embryo.
pubmed:publicationType
Journal Article