Linked Life Data

7180531

Source:http://linkedlifedata.com/resource/pubmed/id/7180531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-2-25
pubmed:abstractText
To examine why intravenous infusion of hypertonic non-electrolyte solutions inhibit pancreatic HCO3(-) secretion, the relationship between pancreatic HCO3(-) secretion and plasma pH was examined before and following intravenous infusion of hypertonic glucose to 5 anesthetized, secretin infused (2.7 C.U./kg b.wt.h-1) pigs. Hyperglycemia (plasma glucose 103 +/- 6 mmol/l) did not significantly change plasma pH, Na+, K+, Cl- and HCO3(-) concentrations. Hyperglycemia reduced pancreatic water flux by 48 +/- 5% and raised pancreatic juice HCO3(-) concentration by 43 +/- 4 mmol/l. Concurrently, HCO3(-) secretion fell by 34 +/- 5%. Acidosis, produced through intravenous HCl infusion and CO2 addition to inspired air, reduced HCO3(-) secretion by 40 +/- 6 mumol/min and 30 +/- 5 mumol/min per 0.1 pH unit reduction in plasma pH before and during hyperglycemia, respectively, and abolished HCO3(-) secretion at an estimated plasma pH of 6.51 +/- 0.06 before and a pH of 6.63 +/- 0.05 during hyperglycemia. We conclude that hypertonic glucose infusions inhibit pancreatic water flux and cause an increase in pancreatic juice HCO3(-) concentration which may inhibit HCO3(-) secretion through an effect on acid-base balance in secretory cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
349-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of intravenous infusion of hypertonic glucose solutions on pancreatic HCO3(-) secretion.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't