Linked Life Data

7175976

Source:http://linkedlifedata.com/resource/pubmed/id/7175976

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-2-14
pubmed:abstractText
Analysis of the carcinogen bioassay of di(2-ethylhexyl) phthalate (DEHP) has shown that the designated maximum tolerated dose was exceeded in the low- and high-dose groups of male rats, in the high-dose group of female rats, and in the low- and high-dose groups of female mice. Significant differences in tumor incidence among small populations of laboratory animals within the testing facility further confounded interpretation of the bioassay. Critical data on food consumption, nutritional status, clinical signs, clinical pathology, and intestinal microorganisms are lacking. This review concludes that because of major deficiencies in the available data, the studies cannot be interpreted as showing a carcinogenic effect due to DEHP alone. Epigenetic mechanisms to explain the biologic effects are examined.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0098-4108
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
493-518
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Comment on the carcinogenic potential of di(2-ethylhexyl) phthalate.
pubmed:publicationType
Journal Article