Linked Life Data

7173394

Source:http://linkedlifedata.com/resource/pubmed/id/7173394

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-2-14
pubmed:abstractText
The turnover of the heme and apocytochrome moieties of phenobarbital-inducible microsomal cytochrome P450 (P450b) was investigated. Adult male Sprague-Dawley rats were treated with phenobarbital for 5 days and injected with [35S]methionine and the heme precursor delta-[3H]-aminolevulinic acid. P450b was isolated by immunoprecipitation and quantitated by rocket immunoelectrophoresis. The isotope disappearance curves revealed a mean half-life (T1/2) of 12.4 h for the heme moiety and a T1/2 of 19.1 h for the apoprotein moiety of P450b. The apparently slower catabolic rate of the apoprotein may be due to reutilization of [35S]methionine and does not exclude synchronous turnover of the two moieties. Our data are consistent with the kinetics of the drug-mediated induction of cytochrome P450b.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
147
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The turnover of cytochrome P450b.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't