Linked Life Data

7173321

Source:http://linkedlifedata.com/resource/pubmed/id/7173321

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1983-2-14
pubmed:abstractText
The phencyclidine(PCP)-like discriminative stimulus properties of the (+)- and (-)-isomers of the prototypic sigma-receptor agonist N-allylnormetazocine (NANM) were evaluated in rats trained to discriminate between saline and 3.0 mg/kg of PCP. The rats were trained under a FR5 schedule of stimulus-shock termination. Both (+)- and (-)-NANM produced PCP-like stimuli and were approximately one-half and one-sixth, respectively, as potent as PCP. The two isomers were equipotent in decreasing response rates. None of the effects of either (+)- or (-)-NANM were antagonized by naloxone. These results demonstrate that the PCP-like effects of NANM exhibit stereoselectivity but not stereospecificity and are additional evidence that the common actions of PCP and NANM are mediated by sigma-receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Phencyclidine-like discriminative stimuli of (+)- and (-)-N-allylnormetazocine in rats.
pubmed:publicationType
Journal Article